Frequently Asked Questions & CBD Misconceptions

-Education

What is CBD?

Cannabidiol, also known as CBD is the name of one of the most numerous compounds found in the cannabis plant. Cannabinoids are a class of active chemical compounds produced by the cannabis plant that are found throughout the seeds, stalk, and flowers of cannabis plants — including hemp and marijuana. These cannabinoids act on receptors located in our cells as part of the endocannabinoid system (ECS) and alter the release of neurotransmitters from body organs, including the brain. The ECS predominantly consists of two endocannabinoid receptors: CB1, located in the central nervous system (CNS), and CB2, found throughout the peripheral nervous system (PNS). Researchers are currently discovering new receptors and are now uncovering that there may be more CB receptors inside of our body.

CBD is the main active compound in hemp and unlike THC, CBD it is not psychoactive, so it does not make you high. Hemp plants have substantial amounts of CBD and only trace amounts of THC which has led to it becoming more popularly recognized for its medicinal purposes. Researchers have been able to identify numerous therapeutic uses of CBD. CBD hemp oil is a natural botanical concentrate.

Scientific and clinical research—much of it sponsored by the US government—underscores CBD’s potential as a treatment for a wide range of conditions, including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and other neurological disorders. CBD has demonstrable neuroprotective and neurogenic effects, and its anti-cancer properties are currently being investigated at several academic research centers in the United States and elsewhere. Further evidence suggests that CBD is safe even at high doses.

CBD doesn’t get you high?

No, CBD doesn’t get you high. CBD is an active phytocannabinoid compound within hemp as well as the whole cannabis plant. It contains no psychoactive effects as compared to THC. You might be wondering how this is possible. It’s because your association of cannabis is to the marijuana plants bread for high THC content – the specific phytocannabinoids that get you high. However, cannabis contains many other phytocannabinoids – most of which do not get you high, like CBD. Some cannabis plants are bred for high CBD content exclusively – these plants are known as ‘hemp’ – and only contain trace amounts of THC (below 0.3% to be exact). The combination of high-CBD with extremely low amounts of THC is what makes the products derived from hemp plants non-psychoactive.

CBD is not psychoactive

CBD is not an intoxicant, but it’s misleading to describe CBD as non-psychoactive. When a clinically depressed patient takes a low dose of a CBD-rich sublingual spray or tincture and has a great day for the first time in a long time, it’s apparent that CBD is a powerful mood-altering compound. Better to say, “CBD is not psychoactive like THC,” than to simply assert that CBD is not psychoactive. CBD won’t make a person feel stoned, but it can impact a person’s psyche in positive ways. Moderate doses of CBD are mildly energizing (“alerting”). But very high doses of CBD may trigger a biphasic effect and can be sleep-promoting. If CBD-rich cannabis flower confers a sedating effect, it’s likely because of a myrcene-rich terpene profile. Myrcene is a terpene with sedative and painkilling properties. CBD is not a sedative.

CBD is most effective without THC

No!, THC and CBD are the power couple of cannabis compounds—they work best together. Scientific studies have established that CBD and THC interact synergistically to enhance each other’s therapeutic effects. British researchers have shown that CBD potentiates THC’s anti-inflammatory properties in an animal model of colitis. Scientists at the California Pacific Medical Center in San Francisco determined that a combination of CBD and THC has a more potent anti-tumoral effect than either compound alone when tested on brain cancer and breast cancer cell lines. And extensive clinical research has demonstrated that CBD combined with THC is more beneficial for neuropathic pain than either compound as a single molecule.

CBD is medical. THC is medicinal as well.

Project CBD receives many inquiries from around the world and oftentimes people say they are seeking “CBD, the medical part” of the plant, “not THC, the recreational part” that gets you high. Actually, THC, “The High Causer,” has awesome therapeutic properties. Scientists at the Scripps Research Center in San Diego reported that THC inhibits an enzyme implicated in the formation of beta amyloid plaque, the hallmark of Alzheimer’s-related dementia.

The federal government recognizes single-molecule THC (Marinol) as an anti-nausea compound and appetite booster, deeming it a Schedule III pharmaceutical, a category reserved for drugs with little abuse potential. But whole plant cannabis, which is the only natural source of THC, continues to be classified as a dangerous Schedule I drug with no medical value.

THC is the bad cannabinoid. CBD is the good cannabinoid.

The drug warrior’s strategic retreat: Give ground on CBD while continuing to demonize THC. Diehard marijuana prohibitionists are exploiting the good news about CBD to further stigmatize high-THC cannabis, casting tetrahydrocannabinol as the bad cannabinoid, whereas CBD is framed as the good cannabinoid. Why? Because CBD doesn’t make you feel high like THC does. Project CBD categorically rejects this moralistic, reffer to madness dichotomy in favor of whole plant cannabis therapeutics. (Read the foundational science paper: A Tale of Two Cannabinoids).

 

-Forms of medicine | Tinctures

¿Qué es una tintura medicinal sublingual?

La tintura medicinal sublingual es un extracto de los principios activos de las partes usadas de las plantas medicinales; para ello se emplea un método de extracción en el cual se sumergen o maceran las plantas. El método de dosificación que se emplea en el uso de las tinturas es por medio de la aplicación de gotas debajo de la lengua.

What is a salve? 

Salves, also known as ointments and unguents, are semi-solid healing mixtures that use herbs and essential oils for their healing properties. They soften when applied topically and provide an excellent barrier that heals, protects, and nourishes wounds, scrapes, abrasions, burns, and even itchy skin.

-Science | Nanotechnology

What is nanotechnology?

Imagine something that is a million times smaller than the length of an ant. Then consider being able to manipulate something so small to solve problems and create new products that can improve the health and well-being of people around the world. Nanotechnology is the understanding, manipulation and control of matter, in dimensions of approximately 1 to 100 nanometers, to produce new materials, devices and structures. A nanometer is one billionth of a meter, the size of a marble compared to the size of planet Earth.

Nano science and nanotechnology imply the ability to see and control individual atoms and molecules. Everything on Earth is made up of atoms: the food we eat, the clothes we wear, the buildings and houses we live in and our own body.

The ideas and concepts behind nano science and nano technology began with a lecture titled “ There’s Plenty of Room at the Bottom: An Invitation to Enter a New Field of Physics”, given by the physicist Richard Feynman at the annual American Physical Society speech given at Caltech on December 29, 1959, way before then term nanotechnology was used.

Dr. Richard Feynman, known as the father of nanotechnology, described a process in which scientists would be able to manipulate and control individual atoms and molecules. More than a decade later, in his explorations of the mechanism of precision, professor Norio Taniguchi coined the term nanotechnology. It wasn’t until 1981, with the development of the tunnel scanning microscope, that the era of modern nanotechnology began, after being able to observe atoms individually.

Single-molecule pharmaceuticals are superior to ‘crude’ whole plant medicinals

According to the federal government, specific components of the marijuana plant (THC, CBD) have medical value, but the plant itself does not have medical value. Uncle Sam’s single-molecule blinders reflect a cultural and political bias that privileges Big Pharma products. Single-molecule medicine is the predominant corporate way, the FDA-approved way, but it’s not the only way, and it’s not necessarily the optimal way to benefit from cannabis therapeutics.

Cannabis contains several hundred compounds, including various flavonoids, aromatic terpenes, and many minor cannabinoids in addition to THC and CBD. Each of these compounds has specific healing attributes, but when combined they create what scientists refer to as a holistic “entourage effect” or “ensemble effect,” so that the therapeutic impact of the whole plant is greater than the sum of its single-molecule parts. The Food and Drug Administration, however, isn’t in the business of approving plants as medicine. (See the scientific evidence.)

References

Burnes, C. (2018). FDA grants first approval of a cannabis-derived medicine. The Pharmaceutical Journal. doi:10.1211/pj.2018.20205071

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